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| L-DNA: Applications and the Recognition of Mirror Image Nucleic Acids |
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When you think about DNA, do you consider its stereochemistry? You should! DNA is a chiral molecule, and consequently, has non-superimposable mirror images (enantiomers). On the other hand, its enantiomer, L-DNA, consists of L-deoxyribose sugars and forms left handed helices.
L-DNA provides a powerful opportunity to develop nucleic acid-based technologies having capabilities not possible using only the native stereoisomer. As more researchers step “Through the Looking-Glass”, and use of mirror image DNA becomes more routine, completely new and exciting applications will become possible. Learn more
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Latest Glen Research Citations
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Evéquoz, D., Verhaart, I. E. C., van de Vijver, D., Renner, W., Aartsma-Rus, A., & Leumann, C. J. (2021). 7’,5’-alpha-bicyclo-DNA: new chemistry for oligonucleotide exon splicing modulation therapy. Nucleic Acids Research, 49(21), 12089–12105. https://go.glenresearch.com/e/835393/10-1093-nar-gkab1097/crks9c/285820010?h=eTgy-ScHGTggFx12n5FvMsySMHFeqpcF34_f4ZvgXnM
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Kupryushkin, M. S., Filatov, A. V., Mironova, N. L., Patutina, O. A., Chernikov, I. V., Chernolovskaya, E. L., Zenkova, M. A., Pyshnyi, D. V., Stetsenko, D. A., Altman, S., & Vlassov, V. V. (2022). Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells. Molecular Therapy. Nucleic Acids, 27, 211–226. https://go.glenresearch.com/e/835393/10-1016-j-omtn-2021-11-025/crks9f/285820010?h=eTgy-ScHGTggFx12n5FvMsySMHFeqpcF34_f4ZvgXnM
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Morihiro, K., Moriyama, Y., Nemoto, Y., Osumi, H., & Okamoto, A. (2021). Anti-syn unnatural base pair enables alphabet-expanded DNA self-assembly. Journal of the American Chemical Society, 143(35), 14207–14217. https://go.glenresearch.com/e/835393/10-1021-jacs-1c05393/crks9h/285820010?h=eTgy-ScHGTggFx12n5FvMsySMHFeqpcF34_f4ZvgXnM
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Pei, X., Zhang, X., Zhang, L., Yuan, M., Sun, L., Yu, F., Wang, B., Zhao, J., He, H., & Yang, V. C. (2021). Targeted exosomes for co-delivery of siFGL1 and siTGF-β1 trigger combined cancer immunotherapy by remodeling immunosuppressive tumor microenvironment. Chemical Engineering Journal (Lausanne, Switzerland: 1996), 421(129774), 129774. https://go.glenresearch.com/e/835393/10-1016-j-cej-2021-129774/crks9k/285820010?h=eTgy-ScHGTggFx12n5FvMsySMHFeqpcF34_f4ZvgXnM
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