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Markers for spontaneous
preterm birth
Our R&D team, in
collaboration with the University Medical Center Groningen and the
University of Groningen, investigated early (first trimester) pregnancy
markers related to spontaneous preterm birth.
Several markers were
found to be differently expressed in the spontaneous preterm birth group
compared to healthy pregnancies. The proteins gelsolin, fibulin-1,
c-reactive protein and complement C5 were altered. These markers are all
to some extent related to inflammatory pathways and/or the complement
system.
Click here to read the full publication.
Cost effectiveness of first trimester screening for preterm
preeclampsia
In this publication,
our R&D team investigated whether testing a biochemical and/or
biophysical marker for preterm preeclampsia in the first trimester is
cost effective in the Netherlands.
The risk of preterm
preeclampsia can be significantly reduced by starting acetylsalicylic
acids ≤16 weeks of gestational age. Recent studies showed that the
predicative models based on maternal risk factors could be improved by
including test results of a biochemical/physical marker.
When compared to the
baseline strategy, the test strategy was estimated to save almost 4
million euros per year on a national scale, and at the same time this
would prevent an additional 228 preterm preeclampsia cases. The study
showed that a first trimester test strategy to screen for preterm
preeclampsia in the first trimester is potentially cost-effective in the
Dutch healthcare setting.
Click here if you wish to read the full publication.
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