Highlights of this month...
First ECMM Excellence Centre
The European Confederation for Medical Mycology (ECMM)
is to promote worldwide collaboration in Medical Mycology, strengthening the information, resources and training available to every country in line with its organisational aims
. To achieve this ECMM is initiating a global network of Centres of Excellence of Medical Mycology, each institute leading the way in its area of specialism.
The first Excellence Centre is to be the Manchester ECMM Excellence Centre based at the Mycology Reference Centre Manchester (MRCM) in partnership with the National Aspergillosis Centre (NAC), both sited at the University Hospital of South Manchester (UHSM) in Wythenshawe, UK.
There will be a launch ceremony held at UHSM along with a series of talks by leading Medical Mycologists and clinicians of the new Centre who will summarise the expertise at the new Centre and ECMM officials who will make it clear why Excellence Centres are needed and what they set out to achieve.
Everyone on the Medical Mycology community and patients & carers are invited to attend the event on 11th January 2017 at the Education and Research Centre, University Hospital of South Manchester, Wythenshawe, Manchester, UK. Talks will begin at 9am and the meeting closes after lunch at 1pm. Register for your place here, free of charge.
|Environmental Aspergillus isolate is source of life threatening infection in immunocompromised patient. Lavergne et.al.
(see articles below) have just published the first paper that demonstrates the isolation of an antifungal resistant strain of Aspergillus fumigatus
from the home of a deceased patient that is identical to the strain isolated from the patient.
Experts in Manchester have recently launched the first e-learning course
in direct microscopy for identifying fungal infection
, also teaching
histological staining methods and interpretation of fungal elements. The
course is accredited by the University of Manchester & will teach
not only how to rapidly and accurately diagnose life-threatening fungal
infections, but also how to set up direct microscopy in a diagnostic
laboratory. It is available at www.microfungi.net
. The first 50 students to complete this course will be offered free ESCMID membership for one year.
The LIFE-Worldwide website
has just published its latest newsletter - read it here
The treatment section has a new article on the link between smoking marijuana and aspergillosis
. Written by Helen Le Suaur this short sub-section reviews 13 published papers and discusses the implications of using marijuana for medicinal purposes to treat AIDS and cancer patients for the alleviation of pain.
Several papers find that samples of marijuana can be heavily contaminated by Aspergillus spores, presumably due to poor control over the drying and storing of the plant material, sometimes stored for extended periods of time.
Cases of aspergillosis have been recorded in patients with cancer, leukemia, transplant and AIDS, though evidence is too weak to demonstrate cause there does seems to be an association between smoking marijuana and aspergillosis under some circumstances and it certainly should be given a lot of thought before marijuana is given to patients with impaired immune systems.
Susceptible strains of Aspergillus fumigatus stop growing when treated with moderate levels of echinocandin antifungal drug but start to grow again if the concentration of drug is increased. This paper finds that overexpression of glucan synthase renders A. fumigatus more susceptible and deletion of glucan synthase removes the ability to grow at high concentrations of echinocandin, suggesting that this paradoxical growth behaviour is dependant on glucan synthesis and glucan synthesis recovers at high levels of echinocandin.
Blood serum levels of some antifungal drugs tend to be very unpredictable so the need to be able to monitor drugs levels quickly and reliably is high. This paper describes a simple and rapid UPLC-MS/MS method for monitoring multiple triazole antifungals that has been developed with a focus on the needs of hospital laboratories. The assay is suitable for clinical utilization and management of patients on these medications. Also see the next article below:
A rapid and accurate method to determine levels of several antifungal drugs in blood serum and urine for the purpose of assisting clinical drug management of patients on these medications (Also see article above and similar articles
In critically ill patients, drug exposure may be influenced by altered drug distribution and clearance. Earlier studies showed that the variability in caspofungin exposure was high in Intensive Care Unit (ICU) patients, and this study takes those observations further by demonstrating that drug exposure of patients in this cohort on a standard dose is low compared to healthy patients. The authors suggest that a weight-based dose regimen is probably more suitable for patients such as these with substantially altered drug distribution.
|A 5-Year Retrospective Review of Avian Diseases Diagnosed at the Department of Pathology, University of Georgia.
827 cases reviewed. Overall, bacterial infection was the most frequently diagnosed cause of death in captive birds, most commonly in Psittaciformes, followed by Passeriformes and Galliformes. Neoplasia was most common in Psittaciformes, which generally are longer lived than other taxa studied. Some disease entities (e.g. atherosclerosis and aspergillosis) may be associated with captive conditions, and some may involve a genetic predisposition (e.g. atherosclerosis, amyloidosis and haemosiderosis).
We have simplified the blogging facility on the Patients website (www.nacpatients.org.uk
) to try to encourage more people to add their own content - writing about event that tell us more about living with aspergillosis or any other relevant material. Write your own blog by registering with the website
and then after logging in go to the blogging page at www.nacpatients.org.uk/blog
and click on 'Create new blog entry' at the top of the page. Then just start typing, upload pictures, add other media. The only limit is your imagination!
December is Christmas Quiz month and this year it was won by Malcolm Birrell with a three way tie for second place. Malcom wins the David MacIntyre Memorial Trophy and get to keep it for a year. Well done to everyone who entered and did so well.
Aspergillosis Community (National Aspergillosis Centre) normally meets on the first friday of each month at the Altounyan Suite, North West Lung Centre, Manchester at 1.30pm BST/GMT. If you can't make it in person, you are welcome to listen in to our live broadcast. On January 6th we will be listening to a talk on the Mediterrenean Diet and why it is good for us - a very suitable subject for many of us after the Christmas excesses!
Our SKYPE trial meeting after the end of this months meeting went very well, to such an extent that I think we can broadcast the entire meeting on SKYPE on January 6th. If you have SKYPE join in on drgraham.atherton - better still contact us first to add your contact details to our SKYPE list and we will contact you after the main meeting.
If you want a text reminder when each meeting is approaching (UK only) then send us an email at email@example.com with your mobile phone number.