November 2019
  Research highlight
The Fate of Aspergilloma Patients After Surgical Treatment-Experience From 22 Cases (Pihlajamaa et al., 2019)
This retrospective analysis of 22 pulmonary aspergilloma patients that underwent surgery in Helsinki, describes clinical backgrounds, anti-fungal medication, indication for surgery, complications, recurrent infections and survival. Surgical treatment of aspergilloma can be life-saving for patients suffering of haemoptysis, and patients with restricted disease and well-preserved pulmonary capacity may benefit from surgery. Careful patient selection is crucial.
  News and notices
December and January are quiet times for conferences so why not take some time this month to consider submitting abstracts or registering to attend the conferences below:
12th Asia-Pacific Microscopy Conference, 3-7 February 2020. Abstract submission has closed but registration is still open.
Fungal Biodiversity 2020, 10-14 February 2020. This course provides a concise overview of the biodiversity of organisms representing the Kingdom Fungi and registration is now open! 
15th European Conference on Fungal Genetics, 17-20 February 2020. The deadline for abstract submission has passed. Registration is now open. Registration closes at midnight on February 5 2020.
9th Advances Against Aspergillosis and Mucormycosis, 27-29 February 2020. Abstract submission is now closed. Registration is open with standard fees of £385 available until 12 January 2020.
17th Annual Conference of the Medical Microbiology and Infectious Diseases Society of Pakistan will be held from 29 February to 01 March 2020, in Lahore. Abstract submission deadline is the 1 January 2020.
Mycology 2020, 13-14 March 2020. The closing date for oral abstracts is midnight 8 February 2020. Poster abstracts close at midnight 24 February 2020. Registration is now open.
The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation, 22-25 March 2020. Abstract submission deadlines for nurses is November 5 2019. For Physicians, Data Management, Quality Management and Statisticians the abstract submission deadline is December 15.
The 30th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 18-21 April 2020. Abstracts submission is closed. Registration is open with early bird fees available until 30 January 2020.
  Research articles
Expanding the Spectrum of Chronic Necrotizing (Semi-Invasive) Aspergillosis: A Series of 8 Cases Presenting as Radiologically Solid Lung Nodules Mimicking Malignancy (Kamtai Dermawan et al., 2019)
This paper provides a good illustration of the difficulties with diagnosis via x-ray or CT scan – 6% of fungal biopsies/resections resembled cancer on imaging and could not be classified as a well-recognized form of aspergillosis.  It also illustrates the difficulty classifying these nodules and lesions into a specific form of aspergillosis and it is necessary to use a range of names i.e. chronic pulmonary, chronic necrotising, semi-invasive etc.
The Clinical Characteristics and Prognosis of ABPA Are Closely Related to the Mucus Plugs in Central Bronchiectasis (Lu et al., 2019)
The characteristics of Allergic Bronchopulmonary Aspergillosis (ABPA) based on its radiological classification is still unclear. This study investigates the clinical significances of ABPA patients with central bronchiectasis (ABPA-CB) by different radiological classifications of mucus plugs. It concludes that the clinical characteristics and prognosis of ABPA-CB patients are closely related to its radiological phenotype of mucus plugs in the central bronchiectasis. The authors recommend that clinicians should promote a diversity of personalised treatments for different patients with different radiological characteristics.
Efficiency of A. fumigatus-Specific IgG and Galactomannan Testing in the Diagnosis of Simple Aspergilloma (Sehgal et al., 2019)
In low and middle-income countries, imaging facilities required for diagnosis of CPA are not always available. This study investigates the role of Aspergillus fumigatus-specific IgG in serum, and galactomannan (GM) in bronchoalveolar lavage fluid (BALF) and serum for the diagnosis of simple aspergilloma as a precursor of CPA. The authors determine the cut‐off value of A. fumigatus‐specific IgG in serum, and GM in BALF and serum, in the diagnosis of SA. Results suggest that A fumigatus‐specific IgG at a cut‐off value of 27 mgA/L has a reasonable diagnostic performance in the workup of SA. The use of serum GM followed by BALF‐GM in addition to A fumigatus‐specific IgG further improves the diagnostic performance.
Prospective Study of the Serum Aspergillus-specific IgG, IgA and IgM Assays for Chronic Pulmonary Aspergillosis Diagnosis (Ma et al., 2019)
This study from China aimed to investigate the diagnostic values of serum Aspergillus-specific IgG, IgA and IgM antibodies in patients with CPA. The sensitivity and specificity of serum Aspergillus-specific IgG assay are satisfactory for diagnosing CPA, while the performance of Aspergillus-specific IgA assay is moderate. Aspergillus-specific IgM assay and serum GM test have limited value for CPA diagnosis.
  Veterinary article
Standing Computed Tomography in Non-anesthetised Little Penguins (Eudyptula minor) to Asses Respiratory System Anatomy and Monitor Disease (Rivas et al., 2019)
MDCT scanning in non-anesthetized little penguins is described. The authors demonstrate it to be a well-tolerated, non-invasive imaging modality for respiratory diseases that are otherwise difficult to diagnose, including aspergillosis and mycobacteriosis.
Endobronchial Aspergilloma - A Comprehensive Literature Review With Focus on Diagnosis and Treatment Modalities (Ngu et al., 2019)
This review focuses on the diagnosis and treatment of endobronchial aspergilloma (EBA), a rare manifestation of pulmonary infection with Aspergillus spp. The authors recommend that EBA should be reclassified under non-invasive forms of pulmonary aspergillosis.
Amyloidosis secondary to chronic pulmonary aspergillosis: Case report and a systematic review of literature (Patel et al., 2019)
This paper contains a case report of chronic pulmonary aspergillosis (CPA) where the initial manifestation was that of nephrotic syndrome due to renal amyloidosis (deposition of abnormally folded proteins in the kidney). This represents an uncommon complication of CPA. The paper also provides a useful review of other studies describing amyloidosis in subjects with CPA.
  Patients and carers
Patient meeting
November’s patient meeting's guest speaker was Dr Jorge Amich from the Manchester Fungal Infection Group at the University of Manchester. Dr Amich delivered a great talk which helped to unravel the Aspergillus fumigatus and Pseudomonas aeruginosa interaction in the context of co-infection. The meeting is available to watch so make sure you catch up!
UK Centre of Moisture in Buildings
This month, Dr Graham Atherton gave a talk about the different forms of aspergillosis (acute/chronic, immunosuppressed/immunocompetent) to the UK Centre of Moisture in Buildings (UKCMB) Annual Conference at the British Research Establishment
The emphasis of the first part of the talk was on the potential impact a damp home might have on causing aspergillosis and on an aspergillosis patient’s quality of life and prognosis. The second half of the talk concentrated on how a multidisciplinary group of construction industry experts, architects, remediators and surveyors combined with specialist academic researchers and clinicians might start to help prevent and reverse the living conditions that cause ill health in a damp building.
ISSE Fellowships for NAC and MRCM staff
Damp homes are the result of multiple problems; structural leaks, rising damp, flooding and inadequate ventilation/condensation. The skills base to detect and correct these defects in UK housing relies upon individual private companies rather than government regulation. The Institute of Specialist Surveyors and Engineers (ISSE) is an independent UK organisation (dating back to 1976) that stands for improvement and management of damp surveyor professional standards and skills. It holds its members to high standards of operation, provides the highest standard of training (ABBE approved) available in the UK and requires members to undergo regular CPD to maintain their status in the organisation. There is also an assurance scheme available to redress any complaints made by a customer of any member of ISSE. ISSE is not a trade organisation so its interests lie in promoting professional standards rather than promoting its members companies.
ISSE has recognised the need for specialist advice on health outcomes caused by damp homes, and has awarded Fellowships to Dr Graham Atherton and Prof Malcolm Richardson who provide regular training talks for members.
Meetings and support
We host a weekly video phone call with around 4-8 patients and a member of NAC staff each week. You can use a computer or mobile device to join the video call by downloading the Zoom software by following this link: This meeting runs from 11:00-12:00 BST every Thursday.
To receive a text reminder when each meeting is approaching send us your mobile phone number (NB this doesn't operate in the US) to
Our meetings for the aspergillosis community occur on the first Friday of each month at the Altounyan Suite, North West Lung Centre, Manchester at 12.30pm BST. If you can't make it in person you are welcome to watch on Facebook. We broadcast live (this is limited to UK patients only) and post the recording so you can watch it in your own time. (Facebook Broadcast
Join our Facebook Groups
  • Our Aspergillosis Support Facebook Group has over 2000 members and is a safe place to meet and talk to other people with aspergillosis. We have a public group and a private group.
  • We also have a Facebook group for carers, friends and family of someone who is affected by the disease - join here
  • To find our regional and international groups, search the following terms within Facebook: 'aspergillosis'; 'aspergillus'; 'ABPA'
Clinical networks
4-6 December, London, UK
3-7 February, 2020
Hyderabad, India
10-14 February 2020
Utrecht, The Netherlands
17-20 February, 2020
Rome, Italy
27-29 February, 2020
Lugano, Switzerland
See more groups and societies
Visit our sites
(free online microscopy course)
(fungal education for clinicians)

Fungal Infection Trust, PO Box 482, Macclesfield, Cheshire SK10 9AR