Review of 34 patients with orbital aspergillosis reporting clinicopathological features, radiologic findings and treatment outcomes.
Conclusions: Isolated orbital aspergillosis though rare should be considered in the differential diagnosis of a patient presenting with a gradually progressive orbital mass, especially in Asian individuals. Early recognition will help reduce the morbidity and mortality associated with this disease.
Tinea capitis(TC) is generally considered as the most frequent fungal infection in childhood, as it accounts for approximately 92% of all mycosis in children. It is well-known and that TC is caused by dermatophytes, which is a scientific label for a group of three genera of fungi: Microsporum, Epidermophyton and Trichophyton.
The authors present two rare cases in young children (4 and 9y.o.) where the infecting organism was Aspergillus niger.
The authors suggest that clinicians in some parts of the world should consider other pathogenic moulds, particularly where a case is resistant to standard treatment.
Class II and V myosins are known to be important for critical cellular processes, including cytokinesis, endocytosis, exocytosis, and organelle trafficking in the model fungi Saccharomyces cerevisiae and Aspergillus nidulans. However, myosins' roles in the growth and virulence of the pathogen Aspergillus fumigatus are unknown.
This study demonstrates that deletion of myoE and myoB reduces virulence in a mouse model system for invasive aspergillosis.
Little is known about the A. fumigatus proteins that trigger the production of Aspergillus-specific IgG antibodies during the course of IA. In order to characterise the serological response to A. fumigatus protein antigens mycelial proteins were separated by 2-D gel electrophoresis.
The authors identified 49 different fungal proteins, which gave a positive IgG antibody signal. Most of these antigens play a role in primary metabolism and stress responses. Overall, their analysis identified 18 novel protein antigens from A. fumigatus, two of which were candidates for further analysis. One candidate (Shm2) induced a strong proimflammatory response, the other (CpcB) didn't - the authors suggest that this finding could be the basis of development of immunotherapy for IA.
Here the authors show that phytochrome-dependent light signalling in Aspergillus nidulans involves the stress-sensing and osmosensing signalling pathway. In a screening for 'blind’ mutants, the MAP kinase SakA (also known as HogA) was identified by whole genome sequencing. The phytochrome FphA physically interacted with the histidine-containing phosphotransfer protein YpdA and caused light-dependent phosphorylation of the MAP kinase SakA and its shuttling into nuclei. In the absence of phytochrome, SakA still responded to osmotic stress but not to light. The SakA pathway thus integrates several stress factors and can be considered to be a hub for environmental signals.