Pub Med US Gov Database - CONCLUSIONS:
"The inclusion of various sulfur-containing functions in organic molecules yielded compounds having whole-body radiation protection from lethal doses of gamma-radiation in animals."
- Ann Pharmacother. 1992 Sep;26(9):1144-7.
Sulfur compounds in therapy: radiation-protective agents, amphetamines, and mucopolysaccharide sulfation. Foye WO. Massachusetts College of Pharmacy and Allied Health Sciences, Boston 02115
*** Sulfur & Radiation Combination Results Cited ***
So there might be LOTS of consequences especially these days of not having lots of natural organic replacement Sulfur food arriving into the body every 12 hours through our diets.
Mark Sircus, Ac., OMD: "the best way to get sulfur into the body is with MSM..."
But there is a plus, it has to be real natural additive free organic Sulfur, from REAL pine tree MSM, not the devitalized cheaper store stuff everyone got bored with.
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- pubmed Results -
Search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Thu Jun 30 20:23:46 2011
Items 1 - 8 of 8
1. Z Naturforsch C. 1980 Sep-Oct;35(9-10):726-8.
Radioprotective and radiosensitizing effects of sulfur-containing amino acid derivatives on mice.
Nishimura A, Hashimoto M, Konno K, Ohta Y, Tahara S, Nishimura H.
Both protection and sensitization of Mice C57Bl against 60Co gamma-rays by sulfur-containing amino acid derivatives--S-alkyl-L-cysteines, S-alkyl-2-methyl-DL-cysteines and their hydantoin derivatives, and sulfoxides of these compounds--were examined. DL-5 Allylthiomethyl-5-methylhydantoin (150 mg/kg body weight) had a remarkable radioprotective effect. The survival ratio was 4.3 or above two times as much as that of L-cysteine. On the other hand, its sulfoxide had a radiosensitizing effects; survival ratio, 0.333.
PMID: 7445679 [PubMed - indexed for MEDLINE]
2. Ann Pharmacother. 1992 Sep;26(9):1144-7.
Sulfur compounds in therapy: radiation-protective agents, amphetamines, and mucopolysaccharide sulfation. Foye WO.
Massachusetts College of Pharmacy and Allied Health Sciences, Boston 02115.
OBJECTIVE: Sulfur-containing compounds have been used in the search for whole-body radiation-protective compounds, in the design of amphetamine derivatives that retain appetite-suppressive effects but lack most behavioral effects characteristic of amphetamines, and in the search for the cause of kidney stone formation in recurrently stoneforming patients.
METHODS: Organic synthetic procedures were used to prepare radiation-protective compounds having a variety of sulfur-containing functional groups, and to prepare
amphetamine derivatives having electron-attracting sulfur functions. In the case of the kidney stone causation research, isolation of urinary mucopolysaccharides (MPS) from recurrently stoneforming patients was carried out and the extent of
sulfation of the MPS was determined by electrophoresis.
RESULTS: Whole-body radiation-protective agents with a high degree of protection against lethal doses of gamma-radiation in mice were found in a series of quinolinium and pyridinium bis(methylthio) and methylthio amino derivatives.
Mechanism studies showed that the copper complexes of these agents mimicked the beneficial action of superoxide dismutase. Electron-attracting sulfur-containing functions on amphetamine nitrogen, as well as 4'-amino nitrogen provided amphetamine derivatives with good appetite-suppressant effects and few or no
adverse behavioral effects. Higher than normal levels of sulfation of the urinary MPS of stone formers suggested a cause for recurrent kidney stone formation. A sulfation inhibitor was found to prevent recurrence of stone formation and inhibit growth of existing stones.
CONCLUSIONS: The inclusion of various sulfur-containing functions in organic molecules yielded compounds having whole-body radiation protection from lethal doses of gamma-radiation in animals.
The presence of electron-attracting sulfur functions in amphetamine gave derivatives that retained appetite-suppressant effects and eliminated most adverse behavioral effects. A therapy for recurrent urolithiasis resulted from inhibition of MPS sulfation, after the finding that stoneforming patients had abnormally high levels of MPS sulfation.
PMID: 1421683 [PubMed - indexed for MEDLINE]
3. Yakugaku Zasshi. 1982 Aug;102(8):774-80.
[Studies on chemical protectors against radiation. XXII. Protective effect of various sulfur containing compounds on skin injury induced by X-irradiation].
[Article in Japanese] Ohta S, Shinoda M.
PMID: 7175696 [PubMed - indexed for MEDLINE]
4. Voen Med Zh. 1987 Aug;(8):24-6.
[Effectiveness of sulfur-containing radioprotectors under various conditions of radiation exposure].
[Article in Russian] Vladimirov VG.
PMID: 3672982 [PubMed - indexed for MEDLINE]
5. Science. 1959 Oct 2;130:861-2.
Protection by sulfur compounds against the air pollutants ozone and nitrogen dioxide. ["Ozone" used here means all kinds of industrial pollutant smog. See "Flood Your Body With Oxygen for details."]
FAIRCHILD EJ 2nd, MURPHY SD, STOKINGER HE.
Two distinct but related pathways of protection against the lethal effects of ozone and nitrogen dioxide are shown by (i) simultaneous inhalation of compounds that furnish -SH or -SS-, or both, and (ii) by injection of thiourea derivatives several days prior to exposure to these oxidant gases. The mechanism of (i) is believed similar to that proposed for the action of radiation-protective compounds; that of (ii) involves the development of a tolerance initiated by the thiourea against the oxidants.
PMID: 13821346 [PubMed - indexed for MEDLINE]
6. J Radiol Prot. 1999 Jun;19(2):171-6.
Caffeine protects mice against whole-body lethal dose of gamma-irradiation. [Coffee beans full of Sulfur]
George KC, Hebbar SA, Kale SP, Kesavan PC.
Biosciences Group, Bhabha Atomic Research Centre, Trombay, Mumbai, India.
Administration of caffeine (1,3,7-trimethylxanthine), a major component of coffee, to Swiss mice at doses of 80 or 100 mg/kg body weight 60 min prior to whole-body lethal dose of gamma-irradiation (7.5 Gy) resulted in the survival of 70 and 63% of animals, respectively, at the above doses in contrast to absolutely no survivors (LD-100/25 days) in the group exposed to radiation alone.
Pre-treatment with a lower concentration of caffeine (50 mg/kg) did not confer any radioprotection. The protection exerted by caffeine (80 mg/kg), however, was reduced from 70 to 50% if administered 30 min prior to irradiation. The trend statistics reveal that a dose of 80 mg/kg administered 60 min before whole-body exposure to 7.5 Gy is optimal for maximal radioprotection. However, caffeine (80 mg/kg) administered within 3 min after irradiation offered no protection. While
there is documentation in the literature that caffeine is an antioxidant and radioprotector against the oxic pathway of radiation damage in a wide range of cells and organisms, this is *** the first report demonstrating unequivocally its potent radioprotective action in terms of survival of lethally whole-body irradiated mice. !!! ***
PMID: 10400154 [PubMed - indexed for MEDLINE]
7. Radiat Res. 1978 Mar;73(3):430-9.
Electronic structure of sulfur compounds and their protecting action against ionizing radiation.
Nagata C, Yamaguchi T.
PMID: 635116 [PubMed - indexed for MEDLINE]
8. Adv Space Res. 1989;9(10):205-12.
Chemical protection against ionizing radiation.
Maisin JR.
Unite de Radiotherapie et de Radioprotection, UCL-Faculte de Medecine, Bruxelles, Belgium.
Abstract. Some of the problems related to chemical protection against ionizing radiation are discussed with emphasis on: definition, classification, degree of protection, mechanisms of action and toxicity. Results on the biological response modifyers (BRMs) and on the combination of nontoxic (i.e. low) doses of sulphydryl radioprotectors and BRMs are presented.
PMID: 11537293 [PubMed - indexed for MEDLINE]
